Detection of NAD(P)H: Quinone Oxidoreductase 609C T Polymorphism in Blood and Archival Human Tissues Using a Simple PCR Method
نویسندگان: ثبت نشده
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C609T Polymorphism of NADPH Quinone Oxidoreductase 1 Correlates Clinical Hematological Toxicities in Lung Cancer Patients Treated with Amrubicin
BACKGROUND Amrubicin hydrochloride (AMR) is a key agent for lung cancer. NADPH quinone oxidoreductase 1 (NQO1) metabolizes the quinone structures contained in both amrubicin (AMR) and amrubicinol (AMR-OH). We hypothesized that NQO1 C609T polymorphism may affect AMR-related pharmacokinetics and clinical outcomes. METHODS Patients received AMR doses of 30 or 40 mg/m(2)/day on days 1-3. Plasma s...
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عنوان ژورنال
دوره 2 شماره 3
صفحات 203- 206
تاریخ انتشار 2004-07-01
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